The Drug Report

Facts about what can go wrong when people use drugs

  • The Best Drug Info Ever?

    A big part of my inspiration for The Drug Report was Beth Pearce's amazing film, VOICE OF THE VICTIMS: TRUE STORIES OF ECSTASY AND KETAMINE. The film simply lets the victims of drug tragedies tell their stories. It's real life, it's undeniable, and it's incredibly powerful. I'm sure Beth has saved many, many lives, and it is my hope that this blog will do so as well. To learn more about her film, go to Voice Of The Victims.


    A friend of mine likes to say, "You're entitled to your own opinion, but not your own facts."

    When it comes to drugs, there are lots of opinions out there: Some think drugs are safe and fun, some think they're dangerous and frightening, and many think everything in between.

    But facts are facts, and when someone dies from drugs, or someone is murdered by a person who is on drugs, or is raped by someone who has given them drugs, that's just a fact. Drug users who actively promote drug use rail against these facts, and I expect they'll be commenting regularly on The Drug Report. But they can't change the facts.

Ecstasy and Hypothermia

Posted by Childress on June 2, 2006

OK, this is a bit of a tough read, but it's important Ecstasy news from a new study released by the National Institutes of Health.  It starts with this eye-catching, if complex, statement:

"Hyperthermia is a potentially fatal manifestation of severe 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) intoxication," physicians in the United States explained.

"No proven effective drug treatment exists to reverse this potentially life-threatening hyperthermia, likely because mechanisms of peripheral thermogenesis are poorly understood," noted J.E. Sprague and colleagues at the National Heart, Lung, and Blood Institute.

That's the sad truth, played out in emergency rooms around the world.

On to Sprague's lab rats:

"Four hours after MDMA treatment, blood was drawn … MDMA induced a 35-fold increase in norepinephrine levels, a 20-fold increase in epinephrine, and a 2.4-fold increase in dopamine levels."  

Ecstasy hard at work.  Sprague and his collegues found that giving the rats carvedilol one hour after ecstasy reversed these hypothermic effects. 

Of course, Ecstasy users who are in distress generally don't get anywhere near a hospital within an hour of taking Ecstasy.  Still, if methods can be found to save people who are near death from Ecstasy use, it will be great news.

One Response to “Ecstasy and Hypothermia”

  1. Dodgy said

    I know this is an old post but it still may appear in searches so I thought it worth pointing out that the title is wrong.

    ‘Hyperthermia’ is condition where the body overheats and ‘Hypo’thermia is th other extreme.

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